Polycystic Kidney Disease
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What is polycystic kidney disease (PKD)?
Polycystic kidney disease (PKD) is a rare genetic disorder. It causes cysts filled with fluid to grow in the kidneys. PKD cysts can impair how the kidneys work. This leads to kidney failure. People with PKD can also have cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain.
PKD is the fourth leading cause of kidney failure. It affects about 600,000 people in the U.S., according to the National Kidney Foundation. About 50% of people with the autosomal dominant form of PKD end up with kidney failure by age 60. About 60% will have kidney failure by age 70.
What are the different types of PKD?
There are 2 main forms of PKD that are inherited:
Autosomal dominant PKD
Autosomal dominant PKD (ADPKD) is the most common form of PKD. It accounts for about 90% of all PKD cases. Autosomal dominant means that if one parent has the disease there is a 50% chance that the disease will pass to a child. Both males and females are equally affected.
ADPKD used to be called adult polycystic kidney disease. It is often diagnosed in adulthood. Usually, at least one parent must have the disease for a child to inherit it. In 10% of cases, there may be no family history of PKD. These cases are new mutations in a family. In very few cases, this type of PKD happens suddenly after conception. Parents would not be at increased risk to have more children with PKD. But people with PKD have a 50/50 chance of passing the gene on to their children.
Symptoms often start between age 30 and 40. But they can begin in childhood. They may include:
ADPKD may happen with other conditions, such as:
The symptoms of ADPKD sometimes look like other health problems. Always see your healthcare provider for a diagnosis.
Diagnosis of ADPKD may include the use of imaging tests to detect cysts on the kidney and other organs and a review of the family history. There are 3 different dominant genes that have been identified. They further subdivide this type into PKD1, PKD2, and PKD3.
A healthcare provider will create a treatment plan after careful consideration of symptoms and medical history. Treatment may include:
Autosomal recessive PKD
Autosomal recessive PKD (ARPKD) is a rare form of PKD. It is thought to be caused by a particular genetic flaw. This is different from the genetic flaw that causes ADPKD. Parents who do not have the disease can have a child with the disease if both parents carry the abnormal gene and both pass the gene to their child. Carrier parents have a 25% chance with each pregnancy to have a child with this type of PKD. Males and females are equally affected.
ARPKD is sometimes found prenatally (before birth) using a fetal ultrasound. Symptoms of can start before birth. In most cases, the earlier the onset, the more severe the outcome.
Children born with ARPKD may develop kidney failure within a few years. They often have:
The disease also usually affects the liver, spleen, and pancreas. This results in low blood cell counts, varicose veins, and hemorrhoids.
The symptoms of ARPKD may look like other health problems. Always talk with a healthcare provider for a diagnosis.
Diagnosis often includes ultrasound imaging of the fetus or newborn to reveal cysts in the kidneys. An ultrasound exam of kidneys of relatives may also be helpful.
A healthcare provider will figure out a treatment plan for ARPKD after careful consideration of the child's symptoms and medical history. Treatment may include:
Online Medical Reviewer: Maryann Foley RN BSN
Online Medical Reviewer: Walead Latif MD